Reevaluation of Antioxidative Strategies for Birth Defect Prevention in Diabetic Pregnancies

Reevaluation of Antioxidative Strategies for Birth Defect Prevention in Diabetic Pregnancies

Diabetes mellitus in early pregnancy is the most severe maternal disease that is counted for 10% of newborn infants with structural defects. With the rapid increases in the number of diabetic women in childbearing age, the birth defect rate is projected to elevate dramatically. Thus, prevention of embryonic malformations becomes an urgent task. Animal studies have revealed an involvement of oxi...

Progesterone for the prevention of preterm birth in women with multiple pregnancies: the AMPHIA trial

BACKGROUND 15% of multiple pregnancies ends in a preterm delivery, which can lead to mortality and severe long term neonatal morbidity. At present, no generally accepted strategy for the prevention of preterm birth in multiple pregnancies exists. Prophylactic administration of 17-alpha hydroxyprogesterone caproate (17OHPC) has proven to be effective in the prevention of preterm birth in women w...

Three-Versus Two-Dimensional Sonographic Biometry for Predicting Birth Weight and Macrosomia in Diabetic Pregnancies.

OBJECTIVES The purpose of this study was to test the hypothesis that a formula incorporating 3-dimensional (3D) fractional thigh volume would be superior to the conventional 2-dimensional (2D) formula of Hadlock et al (Am J Obstet Gynecol 1985; 151:333-337) for predicting birth weight and macrosomia. METHODS We conducted a prospective cohort study of pregnancies complicated by pregestational ...

Glycemic Control in Diabetic Pregnancies

Fetal Surveillance in Diabetic Pregnancies

Diabetes mellitus complicating pregnancy is one of the most common antenatal complications that are associated with significant perinatal mortality and morbidity (Magee et al., 1993; Platt et al., 2002; Schmidt et al., 2001). Diabetic pregnancies can be divided into two categories: those with pre-gestational or pre-existing diabetes mellitus in which the diagnosis is made in the pre-pregnancy s...